Dear Authors,
If you believe that your paper was mistakenly rejected by other leading journals and you do not agree with final decision, the editors of Reports of Practical Oncology and Radiotherapy offer new fast track review. You may submit your manuscript to Reports of Practical Oncology and Radiotherapy together with all prior peer-reviews obtained from the other journal and your rebuttal letter. We guarantee review based decision within 72 hours from the time we will receive your manuscript.

Fast track submission process: Please submit the manuscript with all reviews and rebuttal letter by email to Dr. Michal Masternak ( for fast review processing. To assure immediate attention the email title must to include: RPOR-fast track- Last Name First Name (of corresponding author).

Volume 6, Number 4, 2001

Hormonal therapy and 3 D conformal radiotherapy in localized prostate cancer: early toxicity of combined treatment

Milecki P, Stryczyńska G, Stachowski T, Nawrocki S, Kwias Z.


Purpose: to evaluate acute toxicity of combined treatment (androgen ablation and high-dose 3D conformal radiotherapy [3D-CRT]) in patients with a localized cancer of prostate.
Materials and methods: Between April 1999 and March 2000, at the Greatpoland Cancer Centre in Poznań, 22 patients with prostate cancer (T1-T3 N0 M0) were treated with 3 D conformal radiation therapy and hormonal therapy. Patients represented a localized disease (T1 = 4 patients, T2 = 11 patients), and locally disease (T3 = 7 patients). No patients had clinically detectable distant metastases. Neoadjuvant androgen ablation therapy (bilateral orchiectomy or LH-RH agonists and flutamide) was administered to all patients. Radiotherapy was performed using 15 MV photons in the daily fraction of 1.8 Gy to the total median dose of 70.2 Gy (range, 67.8 to 72 Gy). Acute toxicities were evaluated according to the Radiation Therapy Oncology Group morbidity scoring scale.
Results: All patients completed the entire course of radiotherapy and were assessable for evaluation of acute toxicities. The most common side effects of androgen ablation were "hot flushes" and gynecomastia, although these were mild. The main problems during irradiation and a few weeks after the completion of radiotherapy were related to:
- the genitourinary tract (urgency, nocturia, dysuria) with toxicities of grade 0 and 1 (80% of patients) and grade 2 (20% of patients),
- the gastrointestinal tract (rectal discomfort and mild diarrhea) with toxicities grade 0 and 1 (75% of patients) and grade 2 (25% of patients).
Conclusions: Preliminary results of combined treatment (androgen ablation and 3 D-CRT) have suggested that such modality is well tolerated with only modest acute toxicities of the gastrointestinal and genitourinary tracts.

Signature: Rep Pract Oncol Radiother, 2001; 6(4) : 161-168


« back


Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.